CONTEXT Spinal anaesthesia with hyperbaric lignocaine has the limitation of relatively shorter duration of action, which means that early analgesic intervention is needed in the postoperative period. Intrathecal opioid administration has a promising role in fulfilling this objective. Sufentanil, the congener of fentanyl is 1000 more times potent than morphine is a newer addition to the armoury of modern day anaesthesiologists. AIMS To compare the efficacy of sufentanil and lignocaine combination with lignocaine alone to reduce postoperative pain in patients undergoing perianal under spinal anaesthesia. SETTINGS AND DESIGN A prospective randomized single blinded study conducted after obtaining written informed consent, 100 patients aged above 18 years belonging to ASA Grade I and II scheduled to undergo perianal surgeries under spinal anaesthesia were enrolled in the study. METHODS AND MATERIAL The study population was divided into two groups of 50 each to receive the following treatments: 5% hyperbaric lignocaine 50 mg and 5% hyperbaric lignocaine 50 mg with sufentanil 10 mu g. All the drugs were administered intrathecally. All the patients were explained about the Visual Analog Scale (VAS) and standardized perioperative and anaesthetic procedures were followed. STATISTICAL ANALYSIS All data analysis was completed using SPSS software. Data were expressed as mean+/-SD. Quantitative data was analysed using unpaired 't' test. Side effects were compared by Chi-square test. P extless0.05 was considered as statistically significant. RESULTS There was no variation with regard to the onset of sensory and motor blockade between the two groups. Significant increase in duration of complete and effective analgesia was observed in sufentanil group and the time for first dose of analgesic postoperatively was also significantly delayed. Pruritus was the most common side effect noted in sufentanil group. CONCLUSION Sufentanil potentiates lignocaine anaesthesia by increasing the duration and quality of analgesia and also decreases the ambulation time with minimal side effects.
|Journal||Journal of Evolution of Medical and Dental Sciences|
|Publisher||Akshantala Enterprises Private Limited|