The relationship between individual and organization was explored by examining the influence of perceived organizational support (POS) and psychological well-being (PWB) on organizational commitment. 513 managers working in two large Indian manufacturing organizations were administered standardized measures of POS, PWB, and OC measuring affective commitment (NC), normative commitment (NC), high sacrifice (HiSac), and low alternatives (LoAlt). Regression analysis revealed that POS significantly influenced psychological well-being and all components of organizational commitment. PWB was found to have significant association with AC, NC, and LoAlt. Mediation analysis revealed partial mediation between POS and AC, and POS and NC, and full mediation between POS and LoAlt. A post hoc analysis was carried out to understand the impact of different dimensions of psychological well being on organizational commitment. The implications of the findings are discussed.