Infectious diseases resulting in pandemics remain one of the biggest threats to the wellbeing of the human race. Apart from physiological damage, pandemics have an adverse psychological impact on the victim. The purpose of this paper is to explore the potential psychological and behavioral reactions of H1N1 swine flu pandemic in India 50 individuals residing in India were studied in 2 equivalent groups. The authors performed a comparative analysis of 25 individuals impacted by the H1N1 swine flu pandemic while other group was not impacted by H1N1 swine flu. Two standardized self-report questionnaires were administered to these groups in order to measure the level of stress and fear of personal death. Descriptive statistical analysis was used (mean and standard deviation) and two sample t- test was employed and results indicated that there was a statistically significant difference in level of stress and fear of personal death between the impacted and non-impacted groups.