The emergence of Industry 4.0 and related technologies are changing companies' business model and it’s supply chains. A digital supply chain (DSC) powered by disruptive technologies (DTs) can help organizations to build a sustainable competitive advantage. Although studies on one or some of the DTs gaining momentum over recent years, the literature on DTs adoption in DSC does not report a sufficient number of studies focusing on individual-level adoption behavior. The current study aims to bridge this research gap by examining the determinants of the successful adoption of DTs in DSCs in the USA. Accordingly, this study developed a conceptual model based on the technology–organization–environment (TOE) framework and diffusion of innovation (DOI) theory. Further, this study tested the hypotheses using the PLS-SEM, a partial least squares structural equation modeling. The results indicated that organizational and technology factors influence adoption decisions. Environmental factors such as competitive pressure also play a significant role in DT adoption, but innovation factors do not have any influence whatsoever. Moreover, this study contributes new knowledge to the body of literature on the antecedents of DTs adoption in DSC."